miRNA expression profiles in Smad4-positive and Smad4-negative SW620 human colon cancer cells detected by next-generation small RNA sequencing
Wei Yan, Zhongcai Liu, Wenchao Yang, Guoyang Wu Department of General Surgery, Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004 People’s Republic of China Background and aims: SMAD4, as a tumor suppressive gene in human colon cancer, inhibits the metastasis of colon adenocarcinoma cells.However, the molecular mechanisms are unclea